Jul
03

An exergonic reaction is a chemical reaction where the variation of Gibbs free energy is negative IUPAC Gold Book definition Link. This tells us the direction that the reaction will follow. At constant temperature, constant pressure an exergonic reaction is signified by condition:

<math>\Delta G^\circ < 0</math>

which describes a chemical reaction that releases energy in […]

Mar
28

The Bischler-Napieralski reaction is a chemical reaction that dehydrates an N-acyl β-arylethyl amines into the corresponding heterocycle.

With less nucleophilic aryl groups, more harsh conditions are required. Indoles react readily upon warming in benzene. Benzene rings require higher temperatures.

Phosphorus oxychloride is the most often used dehydrating agent. Phosphorus pentachloride, polyphosphoric acid, and zinc […]